Dr James Wykes | Chris O'Brien Lifehouse
Dr James WykesDirector of Fellowship Program, Head and Neck Surgeon

Dr James Wykes

Director of Fellowship Program, Head and Neck Surgeon

BSci (Med) MBBS (Hons) FRACS


Phone: (02) 9822 5331
(02) 9475 5391


  • General Surgeon – Head and Neck surgery including microvascular reconstruction

Areas of Interest

  • Advanced Cutaneous and Mucosal Tumours
  • Thyroid and Salivary Gland Cancers
  • Head and Neck Reconstruction

James completed his medical training at UNSW in 2005. He undertook his general surgical training in Sydney and completed his FRACS in 2012. He then undertook post-fellowship training in head and neck surgery  and microvascular reconstruction at Liverpool Hospital in 2013, the Sydney Head and Neck Cancer Institute at RPA and Lifehouse in 2014 and St George’s Hospital in London, UK, 2016 in the maxillofacial surgery unit.

James works as a listing medical officer in Head and Neck Surgery at Chris O’Brien Lifehouse, RPA, The Wollongong Hospital, Wollongong Private Hospital and Bankstown Hospital.

His clinical practice encompasses the treatment of cutaneous and mucosal tumours of the head and neck, benign and malignant salivary gland, thyroid and parathyroid gland disease. This includes microvascular free flap reconstruction of the head and neck. James also participates in the general surgery on call roster at Wollongong and Bankstown Hospitals, as well as the facial trauma roster at Wollongong Hospital.

James is the director of the head and neck fellowship program at Chris O’Brien Lifehouse.

His research interests include clinical research in advanced cutaneous and mucosal malignancy of the head and neck, thyroid and salivary gland cancer and microvascular reconstruction outcomes.

Outside of work, James enjoys spending time with his wife and 2 young sons, who all love the great outdoors, especially the beach.

Senior Clinical Lecturer at the University of Sydney

Senior Clinical Lecturer University of Wollongong

Clinical Lecturer UNSW


Book Chapters

James Wykes, Jonathan Clark, Navin Niles: The Role of Sentinel Lymph Node Biopsy in Non-melanoma Skin Cancer of the Head and Neck. Non-melanoma Skin Cancer of the Head and Neck, 01/2015: pages 83-91; , ISBN: 978-81-322-2496-9, DOI:10.1007/978-81-322-2497-6_7

Journal Publications

Kenneth Lai, Slade Matthews, James S. Wilmott, Murray C. Killingsworth, Jim L. Yong, Nicole J. Caixeiro, James Wykes, Allan Samakeh, Dion Forstner, Mark Lee, John McGuinness, Navin Niles, Angela Hong, Ardalan Ebrahimi, Cheok Soon Lee: Differences in LC3B expression and prognostic implications in oropharyngeal and oral cavity squamous cell carcinoma patients. BMC Cancer 12/2018; 18(1)., DOI:10.1186/s12885-018-4536-x

Bryan Minh Tran, David James Roshan, Earl Abraham, Laura Y Wang, Natalia Garibotto, James Wykes, Peter Campbell, Ardalan Ebrahimi: The Prognostic Impact of Tumor Size in Papillary Thyroid Carcinoma is Modified by Age. Thyroid 06/2018; 28(8)., DOI:10.1089/thy.2017.0607

Earl Abraham, Bryan Tran, David Roshan, Susannah Graham, Christopher Lehane, James Wykes, Peter Campbell, Ardalan Ebrahimi: Microscopic positive margins in papillary thyroid cancer do not impact disease recurrence: Microscopic positive margins. ANZ Journal of Surgery 04/2018;, DOI:10.1111/ans.14490

Bryan Tran, David Roshan, Earl Abraham, Laura Wang, Natalia Garibotto, James Wykes, Peter Campbell, Ardalan Ebrahimi: An Analysis of The American Joint Committee on Cancer 8th Edition T Staging System for Papillary Thyroid Carcinoma. Journal of Clinical Endocrinology & Metabolism 04/2018; 103(6)., DOI:10.1210/jc.2017-02551

Ioan Davies, Holly Boyes, James Wykes, Graham Smith: Stafne’s bone cavity − unusual presentation in the anterior mandible. Dental update 04/2018; 45(4):340-341., DOI:10.12968/denu.2018.45.4.340

Joe Jabbour, James Wykes, Chris Milross, Puma Sundaresan, Ardalan Ebrahimi, Heather L. Shepherd, Haryana M. Dhillon, Jonathan R. Clark: Examining clinicians’ perceptions of head and neck cancer (HNC) information. Asia-Pacific Journal of Clinical Oncology 03/2018;, DOI:10.1111/ajco.12858

Ioan Davies, Holly Boyes, Francine Ryba, James Wykes, Nicholas Hyde: Early oral cavity squamous cell carcinoma (pT1): a selective approach to surgical intervention in the neck is justified: a 10-year single centre retrospective review. British Journal of Oral and Maxillofacial Surgery 12/2017; 55(10):e80-e81., DOI:10.1016/j.bjoms.2017.08.345

Francine Ryba, Ioan Davies, Holly Boyes, James Wykes, Nick Hyde: You’re never too old for a free flap. British Journal of Oral and Maxillofacial Surgery 12/2017; 55(10):e126., DOI:10.1016/j.bjoms.2017.08.119

Ioan Davies, Holly Boyes, James Wykes, Francine Ryba, Nicholas Hyde: How new NICE guidelines will impact service provision in patients treated for early oral cavity squamous cell carcinoma – a ten-year single centre retrospective review. British Journal of Oral and Maxillofacial Surgery 12/2017; 55(10):e178-e179., DOI:10.1016/j.bjoms.2017.08.267

Lai, S. Matthews, J. Wilmott, M. Killingsworth, N. Caixeiro, J. Wykes, A. Samakeh, D. Forstner, N. Niles, A. Hong, C.S. Lee: High LC3C expression correlates with poor survival in oral cavity squamous cell carcinoma patients. Pathology 02/2017; 49(1):S141-S142., DOI:10.1016/j.pathol.2016.09.060

Ross K. Smith, James Wykes, David T. Martin, Navin Niles: Perforator variability in the anterolateral thigh free flap: a systematic review. Surgical and Radiologic Anatomy 01/2017; 39(7)., DOI:10.1007/s00276-016-1802-y

Fernandes B, Cherrett C, Moryosef L, Lau N, Wykes J: Nasopharyngeal Carcinoma: Knowledge amongst General Practitioners in Western Sydney. DOI:10.4172/2161-0711.1000517

Kenneth Lai, Murray Killingsworth, Slade Matthews, Nicole Caixeiro, Carlyn Evangelista, Xiao Wu, James Wykes, Alan Samakeh, Dion Forstner, Navin Niles, Angela Hong, Cheok Soon Lee: Differences in Survival Outcome between Oropharyngeal and Oral Cavity Squamous Cell Carcinoma in relation to HPV Status. Journal of Oral Pathology and Medicine 12/2016; 46(8)., DOI:10.1111/jop.12535

Benjamin J Privett, Christopher Lehane, James Wykes, Ardalan Ebrahimi: Sympathetic trunk repair following penetrating injury to the neck. Trauma 07/2016; 19(3)., DOI:10.1177/1460408616655835

Peter P Luk, James Wykes, Christina I Selinger, Rafael Ekmejian, Jessica Tay, Kan Gao, Timothy J Eviston, Trina Lum, Sandra A O’Toole, Jonathan R Clark, Ruta Gupta: Diagnostic and prognostic utility of Mastermind-like 2 (MAML2) gene rearrangement detection by fluorescent in situ hybridization (FISH) in mucoepidermoid carcinoma of the salivary glands. 05/2016; 121(5):530-541., DOI:10.1016/j.oooo.2016.01.003

Weston, J. Wykes, J. Clark: Treatment variations in patients discussed at head and neck multidisciplinary team meetings. International Journal of Oral and Maxillofacial Surgery 10/2015; 44(1):e306., DOI:10.1016/j.ijom.2015.08.381

Peter P. Luk, Christina I. Selinger, James Wykes, Tim Eviston, Rafael Ekmejian, Jess Tay, Trina Lum, Sandra A. O’Toole, Jonathan R. Clark, Ruta Gupta: DIAGNOSTIC AND PROGNOSTIC UTILITY OF MASTERMIND-LIKE 2 (MAML2) GENE REARRANGEMENT DETECTED BY FLUORESCENT IN-SITU HYBRIDISATION (FISH) IN MUCOEPIDERMOID CARCINOMA. Pathology 02/2015; 47:S69., DOI:10.1097/01.PAT.0000461507.93729.63

Shu Wang, James Wykes, Paul R. McKenzie, Chris G. Milross, Michael J. Boyer, Jonathan R. Clark, Ruta Gupta: QUANTIFYING THE CONTRIBUTION OF PATHOLOGY TO PATIENT MANAGEMENT. Pathology 01/2015; 47:S79., DOI:10.1097/01.PAT.0000461546.45309.76

Yufei Chen, James Wykes, Jan Willem Haveman, Christos Apostolou, Neil D Merrett: Laparoscopic repair of Morgagni hernia: an interesting case and complication. ANZ Journal of Surgery 09/2013; 83(9):688-9., DOI:10.1111/ans.12219

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