Breast cancer surgery radiation therapy chemotherapy SPY machine

Dr Cindy Mak MBBS (Hons) FRACS
A/Prof Sanjay Warrier BSc (Med) MBBS FRACS MS

Publications 10
National/International Presentations 4
Grants 10
Students 2

Breast Cancer Research Highlights

Dr Cindy Mak MBBS (Hons) FRACS

A/Prof Sanjay Warrier BSc (Med) MBBS FRACS MS

The breast cancer multidisciplinary team encompasses specialist breast cancer surgeons, pathologists, medical oncologists and radiation oncologists.

A recent study from the group exemplifies the multidisciplinary research done by this group and the longstanding collaboration with The Kinghorn Cancer Centre/ Garvan Institute Breast Cancer Research Group.

Local recurrence and distant failure after adjuvant radiation therapy for breast cancer remain significant clinical problems, incompletely predicted by conventional clinicopathologic markers. The expression of putatice microRNA biomarkers were assessed in a contemporary, prospectively collected series of 458 patients treated with radiation therapy after breast-conserving surgery. Biomarkers of DNA repair and cell cycle control can identify patients at high risk of treatment failure (local recurrence) in those receiving radiation therapy for early breast cancer in independent cohorts. These should be further investigated prospectively, especially TOP2A and SKP2, for which targeted therapies are available.

This year has been highly productive with regards to setting up new research projects in particular with regard to clinical care of breast cancer patients.

The group has commenced a pivotal study looking at the assessment of skin flap viability by a new technology, laser assisted indocyanine green angiography (SPY). This study examines how the SPY assessment impacts a surgeon’s decision making in breast reconstruction surgery. The breast group is also working on projects as diverse as the use of new radiology techniques in breast cancer surgery, the use of different dressings and a study assessing radiology findings in Breastscreen patients and the association with pre-cancerous lesions.

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